Pronunciation: ES-oh-MEP-ra-zole
Generic Name: Esomeprazole
Brand Name: Nexium I.V.
Esomeprazole is used for:
Short-term treatment of gastroesophageal reflux disease (GERD) in patients with irritation and swelling of the esophagus when medicine cannot be taken by mouth. It may also be used for other conditions as determined by your doctor.
Esomeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Do NOT use Esomeprazole if:
- you are allergic to any ingredient in Esomeprazole or to any similar medicine (eg, omeprazole)
- you are taking dasatinib, certain HIV protease inhibitors (eg, atazanavir, nelfinavir), rifampin, or St. John's wort.
Contact your doctor or health care provider right away if any of these apply to you.
Before using Esomeprazole:
Some medical conditions may interact with Esomeprazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood potassium or magnesium levels, liver problems or stomach or bowel cancer
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with Esomeprazole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
- Voriconazole because it may increase the risk of Esomeprazole's side effects
- Ginkgo biloba, rifampin, or St. John's wort because they may decrease Esomeprazole's effectiveness
- Anticoagulants (eg, warfarin), cilostazol, diazepam, digoxin, or saquinavir because the risk of their side effects may be increased by Esomeprazole
- Azole antifungals (eg, ketoconazole), clopidogrel, HIV protease inhibitors (eg, atazanavir, nelfinavir), iron, mycophenolate, or tyrosine kinase inhibitors (eg, dasatinib, erlotinib) because their effectiveness may be decreased by Esomeprazole
This may not be a complete list of all interactions that may occur. Ask your health care provider if Esomeprazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Esomeprazole:
Use Esomeprazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Esomeprazole is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Esomeprazole at home, a health care provider will teach you how to use it. Be sure you understand how to use Esomeprazole. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use Esomeprazole if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- Esomeprazole should only be used for a short time (up to 10 days), until you are able to take medicine by mouth. Discuss any questions or concerns with your doctor.
- Continue to use Esomeprazole even if you feel well. Do not miss any doses.
- If you miss a dose of Esomeprazole, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Esomeprazole.
Important safety information:
- Esomeprazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Esomeprazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds, or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
- Esomeprazole may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use Esomeprazole in high doses, for long periods of time, or if you are older than 50 years. Do NOT take more than the recommended dose or use for longer than prescribed without checking with your doctor. Contact your doctor if you have any questions about this information.
- Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking Esomeprazole for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use Esomeprazole.
- Esomeprazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Esomeprazole.
- Use Esomeprazole with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
- Esomeprazole should be used with extreme caution in CHILDREN younger than 1 month; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Esomeprazole while you are pregnant. It is not known if Esomeprazole is found in breast milk. Do not breast-feed while using Esomeprazole.
Possible side effects of Esomeprazole:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Constipation; diarrhea; drowsiness; dry mouth; gas; headache; nausea; stomach pain.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); bone pain; chest pain; dark urine; fast heartbeat; fever, chills, or sore throat; pain, swelling, or redness at the injection site; red, swollen, blistered, or peeling skin; severe diarrhea; severe stomach cramps or pain; unusual bruising or bleeding; unusual tiredness or weakness; yellowing of the eyes or skin.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
See also: Esomeprazole side effects (in more detail)
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; fast heartbeat; flushing; increased sweating; severe dry mouth, headache, drowsiness, or nausea.
Proper storage of Esomeprazole:
Esomeprazole is usually handled and stored by a health care provider. if you are using Esomeprazole at home, store Esomeprazole as directed by your pharmacist or health care provider. Keep Esomeprazole out of the reach of children and away from pets.
General information:
- If you have any questions about Esomeprazole, please talk with your doctor, pharmacist, or other health care provider.
- Esomeprazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information is a summary only. It does not contain all information about Esomeprazole. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
More Esomeprazole resources
- Esomeprazole Side Effects (in more detail)
- Esomeprazole Use in Pregnancy & Breastfeeding
- Esomeprazole Drug Interactions
- Esomeprazole Support Group
- 54 Reviews for Esomeprazole - Add your own review/rating
- Esomeprazole Professional Patient Advice (Wolters Kluwer)
- esomeprazole Advanced Consumer (Micromedex) - Includes Dosage Information
- Esomeprazole Magnesium Monograph (AHFS DI)
- Nexium Prescribing Information (FDA)
- Nexium Advanced Consumer (Micromedex) - Includes Dosage Information
- Nexium Consumer Overview
- Nexium I.V. Consumer Overview
- Nexium I.V.
Compare Esomeprazole with other medications
- Barrett's Esophagus
- Duodenal Ulcer Prophylaxis
- Erosive Esophagitis
- GERD
- Helicobacter Pylori Infection
- NSAID-Induced Gastric Ulcer
- Pathological Hypersecretory Conditions
- Zollinger-Ellison Syndrome
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